|Year : 2019 | Volume
| Issue : 1 | Page : 20-24
Targeted infection control practices lower the incidence of surgical site infections following total hip and knee arthroplasty in an Indian tertiary hospital
Guda Vaishnavi1, AV Gurava Reddy2, Dinaker Manjunath2, Ganesh Oruganti2, Ramesh Reddy Allam3
1 GYD Diagnostics and Clinics, Hyderabad, India
2 Department of Infection Control, Sunshine Hospitals, Hyderabad, India
3 Department of Infection Control, Sunshine Hospitals, Hyderabad; Department of Health Research, SHARE INDIA, Medchal, Telangana, India
|Date of Web Publication||13-Aug-2019|
Dr. Ramesh Reddy Allam
Deputy Director, SHARE INDIA, MIMS Campus, Ghanpur Village Medchal, Telangana
Source of Support: None, Conflict of Interest: None
Introduction: Deep surgical site infection (SSI) following total knee arthroplasty (TKA) or total hip arthroplasty (THA) is a devastating complication that occurs in approximately 2% of surgical procedures and accounts for 20% of healthcare-associated infections. Despite improvements in prevention, SSI remains a significant clinical problem. Prevention bundles are central to prevent SSI.
Methods: SSIs following TKA/THA are defined by centres for disease control and prevention (CDC) as infections occurring within 1 year post-surgery. Targeted surveillance using prevention bundles for SSIs was instituted among cohort of patients with primary hip and knee arthroplasties from January 2014 to September 2016. Secondary data analysis of the follow-up was done during the physiotherapy appointment and surgical site review visits by the infection control professionals. Infection control team instituted policies and capacity building of known risk factors, such as admitting patients only on day of surgery, pre-operative chlorhexidine bath, hair clipping, timing of antibiotic prophylaxis, glycaemic control, use of High-efficiency particulate air (HEPA) filters and reducing operation theatre traffic. We calculated the incidence, trend and post-operative follow-up of SSIs after universal implementation of bundles.
Results: Among 9666 patients with TKA or THA over 4 years, 8967 were successfully followed up for 1 year. Of the 8967 arthroplasties, 49 cases had SSIs (0.52%). TKA and THA contributed to 89% (42 of 47) and 11% (5 of 47) of the SSIs, respectively. The characteristics of SSIs were 83%, 15% and 2% superficial, deep and organ, respectively. Over the 4 years, the combined SSIs of TKA and THA decreased from 0.79% to 0.34% and the proportion of lost to follow-up decreased from 11.09% to 3.72%. Cases of SSI had co-morbidities such as hypertension, diabetes and others.
Conclusion: Targeted surveillance with adherence to infection control practices significantly reduces the incidence of SSI. Stringent documentation and follow-up of the patients post-surgery will ensure that the SSIs are monitored and attended to.
Keywords: Arthroplasty, infection control, lost to follow-up, surgical site infection, surveillance
|How to cite this article:|
Vaishnavi G, Gurava Reddy A V, Manjunath D, Oruganti G, Allam RR. Targeted infection control practices lower the incidence of surgical site infections following total hip and knee arthroplasty in an Indian tertiary hospital. J Patient Saf Infect Control 2019;7:20-4
|How to cite this URL:|
Vaishnavi G, Gurava Reddy A V, Manjunath D, Oruganti G, Allam RR. Targeted infection control practices lower the incidence of surgical site infections following total hip and knee arthroplasty in an Indian tertiary hospital. J Patient Saf Infect Control [serial online] 2019 [cited 2022 Aug 10];7:20-4. Available from: https://www.jpsiconline.com/text.asp?2019/7/1/20/264398
| Introduction|| |
Surgical site infection (SSI) is an infection of the incision or organ or space that occurs after surgery. The prevention of SSI is increasingly important as the number of surgical procedures performed continues to rise., SSI is an important cause of morbidity and mortality in surgical patients. The overall crude incidence is about 2%–5% of all surgical procedures and accounts for approximately 20% of healthcare-associated infections.,
Total knee and total hip arthroplasties (TKA and THA) are two common surgeries that reduce pain and improve function and quality of life in patients with knee and hip disorders. By 2030, it is projected that orthopaedic surgeons will perform more than 571,000 primary THAs and 3.48 million TKAs in the US alone. From 2006 to 2026, the number of joint arthroplasties are expected to double. If the current infection rates are not decreased, the infection rate will proportionately double as well. It is estimated that 1%–2% of hip implants and 2%–4% of knee implants become infected.
SSIs lead to a large number of post-operative complications and morbidities due to extended hospital stays, additional surgeries and permanent loss of the implant with shortening of the affected limb, deformities, amputation and death. This in turn costs patients both physically and financially. SSI, a potentially devastating complication of lower extremity total joint arthroplasty, is estimated to occur in 1%–2.5% of cases annually. In addition, delayed wound healing may increase the risk for secondary infection. Patients with an SSI have a 2–11 times higher risk of death compared with operative patients without an SSI., Hence, the prevention of SSI becomes particularly important in elective clean surgeries such as TKA and THA.
CDC definition of SSI with regard to TKA and THA considers one of the following criteria: purulence of synovial fluid or growth of the same microorganism in two or more deep samples or acute inflammation in histopathological examination or presence of a sinus tract communicating with the prosthesis over a period of 1 year post-surgery. The time period of such an infection is up to 1 year after surgery.
It has been estimated that approximately half of SSIs are preventable by the application of evidence-based strategies. Good patient preparation, meticulous aseptic practice, attention to surgical technique and timing of antimicrobial prophylaxis are the keys to prevent SSI.
The objective of the study was to demonstrate reduction in the incidence of SSIs following TKA and THA (unilateral and bilateral) surgeries by universal implementation of the 'prevention bundles' in a tertiary hospital.
| Methods|| |
Sunshine Hospital is a multi-speciality 500+-bedded hospital and is globally promoted for joint replacements. The number of surgeries vary from 30 to 50 per day. The hospital is accredited by the National Board for Accreditation of Hospitals (NABH).
Study design, population and inclusion criteria
Secondary data analysis was done on all patients who had either a TKA and/or THA arthroplasty between 1 January 2013 and 30 September 2016 at the Sunshine Hospitals Hyderabad, Telangana State, India, were included in the analysis. The cohort was followed up until 1 year after surgery. SSIs were diagnosed based on the clinical (with signs of inflammation as confirmed by a physician) or microbiological evidence from culture. Patients who had repeat surgery or debridement during the same period were excluded.
The SSIs recorded before January 2014 were considered as baseline during which the prevention bundles were not implemented fully. A structured SSI prevention bundles intervention package was introduced to reduce SSIs during 2014–2016. Th SSIs recorded during 2014-2016 were considered as end line results.
Before January 2014, the hospital did not have a structured SSI prevention plan. In 2014, the Hospital Infection Control Committee (HICC) organised the implementation strategy to prevent SSIs under four known concepts: engage, educate, execute and evaluate. The HICC provided a clear and effective communication pertaining to the reasons why the SSI implementation strategies are important for patient care to the hospital staff and management and obtained support for SSI reduction from senior leadership. Several one-to-one and group education sessions were conducted. Continuing education programmes and capacity building through demonstrations and case-based learning were conducted across various categories of healthcare workers, which included consultants, resident doctors, nurses, house-keeping staff and operation theatre support staff of the hospital.
Targeted surveillance for the prevention of SSIs among TKA and THA patients was implemented from January 2014. The targeted surveillance for the prevention of SSI included the implementation of bundles [Table 1].
Diagnosis of surgical site infections and follow-up
The diagnosis of SSI was made based on the CDC recommendation. Patient case records, temperature logs and microbiology culture reports were reviewed for documented evidence of the SSI. Follow-up was done on week 2, 4, 12, 36 and 52 Post surgery. Telephonic reminders were sent to patients who missed appointments for follow-up.
Infection control nurse was part of the HICC. The infection control nurse was responsible for training the other nurses in the hospital on the implementation of prevention bundles. The HICC developed a checklist to capture the findings of the infection prevention targeting THA and TKA. The formats were digitised every week. The checklist consisted of demographic data, operative notes, indwelling drains and catheters, antibiotics administration and any cultures. Follow-up data were collected at the physiotherapy, dressing and post-operative outpatient departments during the follow-up visit. The physiotherapists were all equally trained to inspect the surgical site, as per the SSI follow-up checklist. Data quality checks were performed by reviewing the source registers and case sheets.
The incidence was calculated using the number of SSI as numerator and duration of follow-up (in years) as denominator. Incidence rates before 2013 and after 2013 were compared to observe the effect of implementing prevention bundles. To assess whether there is significant decrease in incidence post-intervention, a z-test was used. Values were considered statistically significant if P < 0.005. We used SPSS v. 16 (SPSS Inc., Chicago, IL, USA) for data analysis.
Human subject protection
Approval for the study was obtained from the Sunshine Hospitals, Ethics Committee (SS/2018/IEC272).
| Results|| |
During the period 1st January 2013 to 30th September 2016, 9666 patients underwent arthroplasty. More than 80% of the patients were over 50 years of age. About 55% of the patients were females. Of the total 9666 arthroplasty surgeries, 97.58% (9432 of 9666) of them were TKA while the remaining were THA, 5.52% (534 of 9666). The cohort was followed up for 1 year where 8967 were successfully followed. The overall lost to follow-up rate was 7.49% (724 of 9666). The incidence of SSI was 0.52% (49 of 8967). TKA and THA contributed to 89% (42 of 47) and 11% (5 of 47) of SSIs, respectively. Superficial, deep and organ SSIs were 83%, 15% and 2%, respectively [Table 2].
The incidence of SSIs was 0.79% in 2013 and after the intervention was 0.58%, 0.39% and 0.34% from 2014 to 2016, respectively. The reduction in SSI rates after the intervention was statistically significant (Z-value = 8.84, P < 0.0001). The calculated lost to follow-up rates were 11.09% in 2013 to 3.72% in 2016. The incidence of SSI decreased from 0.79% in the pre-implementation phase (2013) to 0.39% in the implementation phase [Figure 1]. Of the 47 infected cases, specimens from 32 patients were sent for culture. Of the 32 specimens, 20 had bacterial growth and predominantly showed growth of methicilllin sensitive satphylococcus aureus (MSSA) (9) [Table 3]. Cases of SSI had co-morbidities such as hypertension, diabetes and others.
|Figure 1: Incidence of surgical site infections after total knee arthroplasties and total hip arthroplasties during 2013–2016|
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|Table 3: Type of organisms isolated from surgical site infections (n=32)|
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Post hoc sample size adequacy assessment
A post hoc sample size calculation was done with the results available from our study. To detect a 50% reduction in incidence from the baseline of 0.79%, with 80% power at 5% level of significance and assuming an average dropout rate of 10% over time, a sample size of 7979 patients would be required. This study used a much larger sample of 9666 patients.
| Discussion|| |
The incidence of SSI in the present study was <1% (0.79–0.34), which is below the reported worldwide incidence of 2.6%–41.9%. Our study is consistent with SSI which was more common in patients of over 55 years of age. This study clearly demonstrated a significant reduction of SSI in knee and hip arthroplasty patients, after strict implementation of the 'prevention bundles' through targeted surveillance., The SSIs from either the TKA or TKA are lower in the baseline too. The lower incidence rates in the baseline could be possibly due to smaller number of trained surgeons operating, and there was an on-going surveillance on hand-washing and environmental measures before the implementation of bundles.
It is however difficult to conclude as to which of the interventions in the prevention bundles were the most effective. Behavioural change pertaining to practise of pre-operative admission to the hospital on the day of surgery and shaving of hair instead of clipping or trimming was a challenging during the implementation process. Timing of antibiotic prophylaxis and cessation of prophylaxis after one dose was followed in true spirit as the senior staff had control over the dosage and prescription.
Additional interventions may have resulted in further reduction in the incidence of SSI; these include minimising the use of peri-operative blood and blood products, prevention of hypothermia by the way of warming blankets, smoking cessation, continued screening and treatment of nasal staphylococcal carriers. Certain additional 'patient-related' factors such as age, nutritional status, obesity, smoking and altered immune response as well as 'operation-related' factors such as duration of surgical scrub, skin anti-sepsis, duration of operation and sterilisation of instruments could also contribute to the SSI. Infected cases in this study had primarily co-morbidities such as hypertension, diabetes and others. The infected cases had longer stay than the un-infected cases. With an aim to decrease the SSIs, the surgeries could be posted when co-morbidities are under-control in all elective cases.
Various studies,, have clearly demonstrated that a surveillance system reporting of SSI to surgeons can reduce SSI. The cost reduction due to reduced infections was calculated to exceed the cost of surveillance (which includes organised control activities, adequate number of trained infection control staff and a system for reporting new cases of SSI) after 2 years.,
Limitation of the study
The follow-up was up to 80% although a near 100% follow-up would have been ideal. Probable reasons for 'lost-to-follow-up' were patients from remote/change of residence and change of contact details. Availability of modern tele-medicine facilities can narrow this gap in future studies.
| Conclusion|| |
The implementation of prevention bundles to prevent SSI through targeted surveillance is a definite cost-effective intervention, especially for patients undergoing TKA and THA, and clearly reduces the incidence of SSI following TKA and THA. Despite the relatively low SSI incidence following orthopaedic surgery and specifically arthroplasty, preventive methods, specifically those targeting Staphylococcus aureus, would serve to minimise costs and improve patient outcomes. The introduction of preventive measures and surveillance coincided with a significant reduction in SSIs following TKA and THA in our institution. Strict evaluation for co-morbidities and surgery after controlled co-morbidities could be a possible solution to decrease SSIs in elective cases.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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[Table 1], [Table 2], [Table 3]